|
T13373 |
YM17E
|
|
Acyltransferase
,
AChR
|
|
|
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T12767 |
RP 70676
|
|
Acyltransferase
|
|
|
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T15109 |
DGAT1-IN-1
|
|
Transferase
|
|
DGAT1-IN-1 is a potent inhibitor of diacylglycerol O- acyltransferase type 1(DGAT1, IC50 of < 10 nM). |
|
T23521 |
VULM 1457
|
|
Acyltransferase
|
|
VULM 1457 is a potent ACAT inhibitor. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM1457 significantly reduces production and secretion of... |
|
T8314 |
RP-64477
|
RP64477 |
Acyltransferase
|
|
RP-64477 is the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT) inhibitor. |
|
T9711 |
OGT-IN-2
|
|
Others
|
|
OGT-IN-2 is a potent O-GlcNAc transferase (OGT) inhibitor. OGT-IN-2 inhibits sOGT and ncOGT with IC50 values of 30 μM and 53 μM, respectively[1]. OGT-IN-2 can be used for the research of articular diseases[1]. |
|
T6937 |
PF-04620110
|
PF04620110,PF 04620110 |
Acyltransferase
,
Transferase
|
|
PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM. |
|
T12425 |
PF-06424439 methanesulfonate
|
|
Acyltransferase
,
Transferase
|
|
PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inh... |
|
T10035 |
10,12-Tricosadiynoic acid
|
TDA,TCDA |
Acyltransferase
|
|
10,12-Tricosadiynoic acid is a highly selective and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1). It can treat the high-fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS me... |
|
T16409 |
OSMI-1
|
|
Others
,
Acyltransferase
|
|
OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans. |
|
T23550 |
YM-750
|
YM 750 |
Acyltransferase
|
|
YM-750 is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with an IC50 value of 0.18 μM. ACAT is an enzyme that catalyzes the conversion of cholesterol and long-chain fatty-acyl-coenzyme A into cholest... |
|
T4681 |
T863
|
DGAT-3,DGAT-1 inhibitor |
Acyltransferase
,
Transferase
|
|
T-863(DGAT-1 inhibitor) is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis... |
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T11733 |
K-604 dihydrochloride
|
|
Acyltransferase
|
|
K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 inhibitor with an IC50 of 0.45±0.06 μM. |
|
T8236 |
RHC 80267
|
U-57908 |
Others
,
Phospholipase
,
COX
,
Acyltransferase
,
AChR
|
|
RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets) |
|
T22665 |
PD 128042
|
CI 976 |
Acyltransferase
|
|
PD 128042 (CI 976) is a potent orally active and selective ACAT inhibitor(IC50: 73 nM) and a potent lysophospholipid acyltransferase(LPAT) inhibitor. CI 976 inhibits Golgi-associated LPAT activity (IC50: 15 μM) and multi... |
|
T12225L |
Nevanimibe hydrochloride
|
PD-132301 hydrochloride,ATR101 hydrochloride |
Apoptosis
,
Acyltransferase
|
|
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM). |
|
T2753 |
Avasimibe
|
PD-148515,CI-1011 |
P450
,
Acyltransferase
|
|
Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenz... |
|
T15247 |
ESI-05
|
NSC 116966 |
cAMP
|
|
ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation. |
|
T6365 |
A 922500
|
A922500,DGAT-1 Inhibitor 4a |
Acyltransferase
,
Transferase
|
|
A 922500 (DGAT-1 Inhibitor 4a) is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets. |
|
T12426 |
PF-06424439
|
|
Acyltransferase
,
Transferase
|
|
|
|
T14523 |
Beauvericin
|
|
Others
,
Acyltransferase
|
|
Beauvericin, a Fusarium mycotoxin, inhibits acyl-CoA:cholesterol acyltransferase (ACAT) in rat liver microsomal enzyme assays with an IC50 value of 3 μM. |
|
T25635 |
Lateritin
|
Bassiatin |
Acyltransferase
|
|
Lateritin (Bassiatin) is An Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor and a platelet aggregation inhibitor from the mycelial cake of Gibberella lateritium. Bassiatin is the (3S,6R) isomer. |
|
T36126 |
TMP-153
|
|
|
|
Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and choleste... |
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T25891 |
NTE-122
|
NTE 122 |
|
|
NTE-122 is a competitive Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. |
|
T15346 |
FR-190809
|
|
Others
|
|
FR-190809 is a nonadrenotoxic and orally efficacious inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) (IC50: 45 nM). |
|
T27376 |
FR-186054
|
FR186054,FR 186054 |
|
|
FR-186054 is a new, potent inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) and has oral activity. Compared to other ACAT inhibitors, this compound displayed excellent in vitro efficacy, irrespective of dosing ... |
|
T70356 |
F-1394
|
|
|
|
F-1394 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. F-1394 both prevents the formation of atherosclerosis and accelerates its regression without affecting the serum TC level, indicating that F-1394 acts ... |
